What is Clomipramine Hydrochloride? The Benefits of a Generic Anti-Anxiety Medication

It is not yet fully understood why some dogs suffer from separation anxiety and others don’t. Studies have been unable to pinpoint the exact causes, but experts have indicated that 20 to 40 percent of dogs face distress symptoms that exhibit separation anxiety. The main contributing factor to anxiety in dogs is fear. Examples may include if a dog is in an unfamiliar environment, if it is unable to seek comfort or safety or if it has suffered from previous trauma. Fear is the common denominator, so it is important to instill a sense of calm and trust.

sad beagle with depression anxiety

Separation Anxiety in Dogs – Common Symptoms

Furthermore, symptoms of separation anxiety may be triggered if a dog’s owners suddenly leave the house or are preparing to leave. You may recall a time when you’ve been packing for a vacation and your dog begins shaking or even jumps into the suitcase. These behaviors are indicative of behavioral issues that could be diagnosed as separation anxiety. Left untreated, a dog may react in a variety of destructive and agitated ways that could cause damage to your household or themselves (e.g., chewing, panting, drooling, urinating).


Additionally, specialists have observed that dogs who have gone through a shelter or were adopted from another household tend to display these symptoms more frequently. For canine owners it’s important to learn management techniques for their pets who may be suffering from separation anxiety.

Clomipramine Hydrochloride Tablets – FDA Approved Solution


Fortunately, the Food and Drug Administration (FDA) approved a name brand medication to support the treatment of separation anxiety in canines twenty years ago. Most recently, the FDA approved clomipramine hydrochloride tablets, a generic form of this separation anxiety prescription medication.

Clomipramine hydrochloride tablets are an anti-anxiety medication. Specifically, clomipramine is a tricyclic antidepressant, which affects chemicals in the brain associated with positive emotions (Serotonin). When used as prescribed and in combination with a behavior modification program, Clomipramine can reduce the clinical signs associated with separation anxiety in dogs.

happy husky taking clomipramine hydrochloride tablets for depression anxiety

This generic version is a therapeutically equivalent copy of its name brand counterparts. That means that it has exactly the same dosage, intended use, and effect, as the pioneer drug. Like name brand drugs, generic medications go through rigorous testing by the FDA. To ensure quality, safety, and effectiveness, the FDA thoroughly evaluates all generic drugs including a comprehensive review of the manufacturing process, evaluating the drug’s potency and purity, while simultaneously evaluating how the generic drug performs in the animal’s body.

Generic Dog Medications – An Effective Alternative to Name Brand Drugs

Generic medications are known for being less expensive than the name brand versions. Because the manufacturing and availability of generic medicines are often faster to approval, this results in significant cost savings to the consumer. Ultimately, you have a more cost effective alternative to treatment without jeopardizing safety or quality.


For pet owners whose dog show symptoms of separation anxiety, clomipramine hydrochloride tablets, in addition to regular training, may help make your dog more comfortable when you reach for the keys to leave your house.


Mizner Bioscience’s Clomipramine HCl Tablets are available as beef flavored tablets in four strengths: 5.00 mg, 20.00 mg, 40.00 mg and 80.00 mg. Notably, Mizner Bioscience is the only company to offer a 40 mg tablet making it a convenient option for pet owners whose dogs fall within the 22-44 pound weight range. Clomipramine is available by prescription in the form of tablets.


If you have questions about the current anxiety medication your dog is on, or want to make the cost saving switch to generic medications, consult with your veterinarian and ask about Clomipramine Hydrochloride generic tablets.

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